Frontline Plus (aka Frontline Combo)

In Stock
Brand: Merial
Product Code: Frontline

Available Options

Brand Name

Frontline Plus (Merial)


Generic Name

Fipronil, S-methoprene


Product Description

Frontline Plus is a comprehensive flea, tick, and lice treatment for dogs and cats. A single dose strikes quickly and remains effective for 30 days to kill all flea eggs, larvae and adult fleas. It also kills the major species of ticks and helps to control chewing lice and prevent sarcoptic mange infestations.



  • Quick Acting: Kills virtually all fleas within 12 hours and all ticks within 48 hours.
  • Long Lasting: Active for one full month following application.
  • Versatile: Prevents infestation of chewing lice and ticks as well as fleas and also helps to control sarcoptic mange infections.
  • Disease Prevention: Helps to prevent instances of flea allergy dermatitis, as well as diseases carried by ticks such as Lyme disease.
  • No Expiry Date: Keep Frontline Plus sealed in original packaging at room temperature and it will be effective no matter when you choose to use it.
  • Waterproof: After it is absorbed, Frontline Plus continues to work even after swimming, bathing and grooming.


How It works

Applied topically, Frontline Plus’s two active ingredients (fipronil & S-methoprene) become embedded in the oil glands of cats and dogs. Fipronil is a broad spectrum insecticide which poisons fleas and ticks, destroying their central nervous system. S-methoprene kills the eggs and larvae of fleas.

This provides full coverage against fleas and ticks in all stages of their lifecycle. These chemicals continuously release themselves into the pet’s hair and skin by way of the hair follicles, killing any fleas and ticks which come in contact with it.



Frontline Plus is topically applied. Users should wait 24 hours before bathing their pet or letting their pet swim after application. It is also important to ensure that your pet is completely dry when Frontline Plus is applied.

To use, first remove the applicator from the packaging. Then, crack open the tip of the applicator facing away from the face and body. Finally, squeeze and spread the solution along the area between the pet’s shoulder blades, where the pet cannot lick it.

Users should choose a size of applicator which is right for the size of their pet.




Dogs/Puppies of 8 weeks and older weighing up to 22 lbs

One .67ml (orange) applicator per month

Dogs/Puppies of 8 weeks and older weighing 23 to 44 lbs

One 1.34 ml (blue) applicator per month

Dogs/Puppies of 8 weeks and older weighing 45 to 88 lbs

One 2.68 ml (purple) applicator per month

Dogs/Puppies of 8 weeks and older weighing 89 to 132 lbs

One 4.02 ml (red) applicator per month

Cats/Kittens of 8 weeks and older of any weight

One 0.5 ml (green) applicator per month


Effects start becoming noticeable four hours after application and continue for a month. Twelve hours after application, nearly 100% of existing fleas should be killed.



  • If your pet is on any other medications, consult with a veterinarian before applying Frontline Plus.
  • Some discomfort or irritation may occur in the area where Frontline Plus was applied. Pay attention to the area following the application to ensure that skin irritation does not escalate. If the situation continues to get worse, talk to a veterinarian immediately.
  • Do not apply Frontline Plus more than once a month. Consult a veterinarian immediately if an overdose occurs.
  • Do not apply Frontline plus to pets younger than 8 weeks.
  • Do not apply Frontline Plus to any animals other than dogs and cats.
  • Consult your veterinarian before applying Frontline Plus to a pet to which you have already applied a different flea/tick treatment.
  • Frontline Plus is flammable.
  • Swallowing Frontline Plus is harmful to humans. If swallowed, consult a physician or poison control.
  • Keep away from human eyes and skin.
  • Completely wash hands with soap and water after use.
  • Ensure that Frontline Plus is kept in a place which is inaccessible to children and pets.


Additional Information


How Should I store Frontline Plus?

Frontline Plus should be kept at room temperature in its original packaging. If kept this way, it will never expire. Frontline Plus should also be kept away from children and pets.


If I forget to give my pet a dose of Frontline Plus, what should I do?

Dose your pet as soon as you remember. If your pet is close to its next scheduled dose, wait until then. Do not apply more than a single dose to your pet at one time as compensation for a missed dose.


What sorts of ticks does Frontline Plus fight against?

Frontline Plus kills brown dog ticks, lone star ticks, American dog ticks and deer ticks (carriers of Lyme disease).


Are there any side effects?

Side effects, while rare, can include skin irritation at the site of the application. Pay attention to this area after application to watch for signs of irritation. If the severity of irritation progresses, see a veterinarian immediately.


Is there a difference between Frontline Plus and Frontline Combo?

Frontline Combo is the UK version of Frontline Plus. It contains identical active ingredients to Frontline Plus (Fipronil & S-methoprene).


Why do more fleas appear on my pet after applying Frontline Plus?

This is a good thing. As fleas die from the effects of frontline plus, they will rise to the top of the coat of the pet.


Does Frontline Plus only work when my fleas and ticks bite my pet?

No. Frontline Plus is fatal to fleas and ticks on contact. 

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